Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.
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چکیده
منابع مشابه
The Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
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This study investigated the effects of glial cell line-derived neurotrophic factor (GDNF) on dental pulp stromal cells (DPCs). Cultures of DPCs expressed GDNF as well as its receptors, GFR1 and RET. Addition of recombinant GDNF to cultures in serumcontaining medium did not significantly affect DPC growth; however, GNDF dosedependently increased viable cell number under serum-free culture condi...
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objective(s)progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. in recent years, the neuroprotective effects of progesterone have attracted growing interest. glial cell line-derived neurotrophic factor (gdnf), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
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Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic acid and epidermal growth factor. Cell viability, microtubule-associated protein 2-positive cell ratio, and the expression levels of glial cell line-derived neurotrophic factor, ne...
متن کاملThe Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have bee...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.20.9092